About Methylosome subunit pICln
Methylosome subunit pICln (CLNS1A) is a protein
from Homo sapiens identified by UniProt accession
P54105, 237 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Methylosome subunit pICln |
|---|
| UniProt accession | P54105 |
|---|
| Gene | CLNS1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 237 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.23
- lysosomal storage disease · score 0.23
- Parkinson disease · score 0.23
- multiple sclerosis · score 0.23
- neurodegenerative disease · score 0.23
- platelet component distribution width · score 0.10
- appendicular lean mass · score 0.07
- mean platelet volume · score 0.06
- grip strength measurement · score 0.06
- diastolic blood pressure · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54105-F1 | alphafold | PREDICTED | 75.50 | — |
Amino-acid sequence (237 residues)
MSFLKSFPPP GPAEGLLRQQ PDTEAVLNGK GLGTGTLYIA ESRLSWLDGS GLGFSLEYPT ISLHALSRDR SDCLGEHLYV MVNAKFEEES KEPVADEEEE DSDDDVEPIT EFRFVPSDKS ALEAMFTAMC ECQALHPDPE DEDSDDYDGE EYDVEAHEQG QGDIPTFYTY EEGLSHLTAE GQATLERLEG MLSQSVSSQY NMAGVRTEDS IRDYEDGMEV DTTPTVAGQF EDADVDH
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