Cysteine-rich secretory protein 1 (CRISP1)

About Cysteine-rich secretory protein 1

Cysteine-rich secretory protein 1 (CRISP1) is a protein from Homo sapiens identified by UniProt accession P54107, 249 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Cysteine-rich secretory protein 1
UniProt accession	P54107
Gene	CRISP1
Organism	Homo sapiens
Length	249 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.13
gut microbiome measurement · score 0.11
drug use measurement · score 0.07
glucuronate measurement · score 0.05
familial male-limited precocious puberty · score 0.05
Testicular regression syndrome · score 0.04
spermatogenic failure, X-linked, 2 · score 0.04
body mass index · score 0.03
cardiovascular disease · score 0.03
Isolated follicle stimulating hormone deficiency · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54107-F1	alphafold	PREDICTED	93.17	—

Amino-acid sequence (249 residues)

MEIKHLLFLV AAACLLPMLS MKKKSARDQF NKLVTDLPNV QEEIVNIHNA LRRRVVPPAS NMLKMSWSEE AAQNARIFSK YCDMTESNPL ERRLPNTFCG ENMHMTSYPV SWSSVIGVWY SESTSFKHGE WTTTDDDITT DHYTQIVWAT SYLIGCAIAS CRQQGSPRYL YVCHYCHEGN DPETKNEPYK TGVPCEACPS NCEDKLCTNP CIYYDEYFDC DIQVHYLGCN HSTTILFCKA TCLCDTEIK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards