Cysteine-rich secretory protein 3 (CRISP3)

About Cysteine-rich secretory protein 3

Cysteine-rich secretory protein 3 (CRISP3) is a protein from Homo sapiens identified by UniProt accession P54108, 245 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.

Target properties

Protein name	Cysteine-rich secretory protein 3
UniProt accession	P54108
Gene	CRISP3
Organism	Homo sapiens
Length	245 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (140)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.36
gut microbiome measurement · score 0.16
retinitis pigmentosa · score 0.11
age-related macular degeneration · score 0.09
PHF-tau measurement · score 0.08
X-linked retinal dysplasia · score 0.08
esophageal squamous cell carcinoma · score 0.08
Progressive cone dystrophy · score 0.07
Familial exudative vitreoretinopathy · score 0.07
severe early-childhood-onset retinal dystrophy · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54108-F1	alphafold	PREDICTED	92.50	—

Amino-acid sequence (245 residues)

MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR EIVNKHNELR RAVSPPARNM LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL YMSSASSSWS QAIQSWFDEY NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR LYVPYEQGAP CASCPDNCDD GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC SNSIY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards