Ataxin-3 (ATXN3)

About Ataxin-3

Ataxin-3 (ATXN3) is a protein from Homo sapiens identified by UniProt accession P54252, 361 residues long. MolForge cross-references it against 0 known binders and 229 disease associations.

Target properties

Protein name	Ataxin-3
UniProt accession	P54252
Gene	ATXN3
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (229)

Diseases linked to this target (Open Targets).

Machado-Joseph disease · score 0.55
Spinocerebellar ataxia type 3 · score 0.52
Machado-Joseph disease type 2 · score 0.37
Machado-Joseph disease type 1 · score 0.37
Machado-Joseph disease type 3 · score 0.37
high density lipoprotein cholesterol measurement · score 0.34
heel bone mineral density · score 0.32
alkaline phosphatase measurement · score 0.29
vital capacity · score 0.24
apolipoprotein A 1 measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54252-F1	alphafold	PREDICTED	75.88	—

Amino-acid sequence (361 residues)

MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards