About Huntingtin-associated protein 1
Huntingtin-associated protein 1 (HAP1) is a protein
from Homo sapiens identified by UniProt accession
P54257, 671 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Huntingtin-associated protein 1 |
|---|
| UniProt accession | P54257 |
|---|
| Gene | HAP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 671 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- esophageal carcinoma · score 0.17
- squamous cell carcinoma · score 0.17
- viral load · score 0.09
- peptic ulcer disease · score 0.07
- heel bone mineral density · score 0.06
- obesity due to leptin receptor gene deficiency · score 0.04
- bulimia nervosa · score 0.04
- infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly · score 0.03
- hypouricemia, renal, 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54257-F1 | alphafold | PREDICTED | 63.18 | — |
Amino-acid sequence (671 residues)
MRPKRLGRCC AGSRLGPGDP AALTCAPSPS ASPAPEPSAQ PQARGTGQRV GSRATSGSQF LSEARTGARP ASEAGAKAGA RRPSAFSAIQ GDVRSMPDNS DAPWTRFVFQ GPFGSRATGR GTGKAAGIWK TPAAYVGRRP GVSGPERAAF IRELEEALCP NLPPPVKKIT QEDVKVMLYL LEELLPPVWE SVTYGMVLQR ERDLNTAARI GQSLVKQNSV LMEENSKLEA LLGSAKEEIL YLRHQVNLRD ELLQLYSDSD EEDEDEEEEE EEKEAEEEQE EEEAEEDLQC AHPCDAPKLI SQEALLHQHH CPQLEALQEK LRLLEEENHQ LREEASQLDT LEDEEQMLIL ECVEQFSEAS QQMAELSEVL VLRLENYERQ QQEVARLQAQ VLKLQQRCRM YGAETEKLQK QLASEKEIQM QLQEESVWVG SQLQDLREKY MDCGGMLIEM QEEVKTLRQQ PPVSTGSATH YPYSVPLETL PGFQETLAEE LRTSLRRMIS DPVYFMERNY EMPRGDTSSL RYDFRYSEDR EQVRGFEAEE GLMLAADIMR GEDFTPAEEF VPQEELGAAK KVPAEEGVME EAELVSEETE GWEEVELELD EATRMNVVTS ALEASGLGPS HLDMNYVLQQ LANWQDAHYR RQLRWKMLQK GECPHGALPA ASRTSCRSSC R
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