Telomeric repeat-binding factor 1 (TERF1)

About Telomeric repeat-binding factor 1

Telomeric repeat-binding factor 1 (TERF1) is a protein from Homo sapiens identified by UniProt accession P54274, 439 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.

Target properties

Protein name	Telomeric repeat-binding factor 1
UniProt accession	P54274
Gene	TERF1
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (166)

Diseases linked to this target (Open Targets).

telomere length · score 0.59
neurodegenerative disease · score 0.52
head and neck squamous cell carcinoma · score 0.26
ovarian cancer · score 0.23
gastroesophageal reflux disease · score 0.23
lung adenocarcinoma · score 0.21
squamous cell lung carcinoma · score 0.21
esophageal cancer · score 0.21
gastric adenocarcinoma · score 0.21
Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54274-F1	alphafold	PREDICTED	71.09	—

Amino-acid sequence (439 residues)

MAEDVSSAAP SPRGCADGRD ADPTEEQMAE TERNDEEQFE CQELLECQVQ VGAPEEEEEE EEDAGLVAEA EAVAAGWMLD FLCLSLCRAF RDGRSEDFRR TRNSAEAIIH GLSSLTACQL RTIYICQFLT RIAAGKTLDA QFENDERITP LESALMIWGS IEKEHDKLHE EIQNLIKIQA IAVCMENGNF KEAEEVFERI FGDPNSHMPF KSKLLMIISQ KDTFHSFFQH FSYNHMMEKI KSYVNYVLSE KSSTFLMKAA AKVVESKRTR TITSQDKPSG NDVEMETEAN LDTRKSVSDK QSAVTESSEG TVSLLRSHKN LFLSKLQHGT QQQDLNKKER RVGTPQSTKK KKESRRATES RIPVSKSQPV TPEKHRARKR QAWLWEEDKN LRSGVRKYGE GNWSKILLHY KFNNRTSVML KDRWRTMKKL KLISSDSED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards