About Mismatch repair endonuclease PMS2
Mismatch repair endonuclease PMS2 (PMS2) is a protein
from Homo sapiens identified by UniProt accession
P54278, 862 residues long.
MolForge cross-references it against 0 known binders and
486 disease associations.
Target properties
| Protein name | Mismatch repair endonuclease PMS2 |
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| UniProt accession | P54278 |
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| Gene | PMS2 |
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| Organism | Homo sapiens |
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| Length | 862 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (486)
Diseases linked to this target (Open Targets).
- Lynch syndrome · score 0.84
- Constitutional mismatch repair deficiency syndrome · score 0.75
- mismatch repair cancer syndrome 1 · score 0.68
- mismatch repair cancer syndrome · score 0.66
- endometrial carcinoma · score 0.62
- hereditary neoplastic syndrome · score 0.58
- Inherited cancer-predisposing syndrome · score 0.58
- hereditary nonpolyposis colorectal carcinoma · score 0.56
- hereditary nonpolyposis colon cancer · score 0.56
- Hereditary breast and ovarian cancer syndrome · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54278-F1 | alphafold | PREDICTED | 70.97 | — |
Amino-acid sequence (862 residues)
MERAESSSTE PAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSLDAG ATNIDLKLKD YGVDLIEVSD NGCGVEEENF EGLTLKHHTS KIQEFADLTQ VETFGFRGEA LSSLCALSDV TISTCHASAK VGTRLMFDHN GKIIQKTPYP RPRGTTVSVQ QLFSTLPVRH KEFQRNIKKE YAKMVQVLHA YCIISAGIRV SCTNQLGQGK RQPVVCTGGS PSIKENIGSV FGQKQLQSLI PFVQLPPSDS VCEEYGLSCS DALHNLFYIS GFISQCTHGV GRSSTDRQFF FINRRPCDPA KVCRLVNEVY HMYNRHQYPF VVLNISVDSE CVDINVTPDK RQILLQEEKL LLAVLKTSLI GMFDSDVNKL NVSQQPLLDV EGNLIKMHAA DLEKPMVEKQ DQSPSLRTGE EKKDVSISRL REAFSLRHTT ENKPHSPKTP EPRRSPLGQK RGMLSSSTSG AISDKGVLRP QKEAVSSSHG PSDPTDRAEV EKDSGHGSTS VDSEGFSIPD TGSHCSSEYA ASSPGDRGSQ EHVDSQEKAP KTDDSFSDVD CHSNQEDTGC KFRVLPQPTN LATPNTKRFK KEEILSSSDI CQKLVNTQDM SASQVDVAVK INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA EDELRKEISK TMFAEMEIIG QFNLGFIITK LNEDIFIVDQ HATDEKYNFE MLQQHTVLQG QRLIAPQTLN LTAVNEAVLI ENLEIFRKNG FDFVIDENAP VTERAKLISL PTSKNWTFGP QDVDELIFML SDSPGVMCRP SRVKQMFASR ACRKSVMIGT ALNTSEMKKL ITHMGEMDHP WNCPHGRPTM RHIANLGVIS QN
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