About Voltage-dependent L-type calcium channel subunit beta-3
Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) is a protein
from Homo sapiens identified by UniProt accession
P54284, 484 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Voltage-dependent L-type calcium channel subunit beta-3 |
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| UniProt accession | P54284 |
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| Gene | CACNB3 |
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| Organism | Homo sapiens |
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| Length | 484 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.48
- generalized anxiety disorder · score 0.39
- Urinary incontinence · score 0.37
- gastrointestinal disease · score 0.37
- Polyuria · score 0.37
- anxiety · score 0.27
- thyroid gland adenocarcinoma · score 0.26
- breast adenocarcinoma · score 0.26
- glioblastoma multiforme · score 0.22
- cutaneous melanoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54284-F1 | alphafold | PREDICTED | 73.92 | — |
Amino-acid sequence (484 residues)
MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS PQRLESIRLK QEQKARRSGN PSSLSDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT HHPAPGPGLL GPPSAIPGLQ NQQLLGERGE EHSPLERDSL MPSDEASESS RQAWTGSSQR SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHNHSD RNWQRNRPWP KDSY
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