About Inactive pancreatic lipase-related protein 1
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) is a protein
from Homo sapiens identified by UniProt accession
P54315, 467 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Inactive pancreatic lipase-related protein 1 |
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| UniProt accession | P54315 |
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| Gene | PNLIPRP1 |
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| Organism | Homo sapiens |
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| Length | 467 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.42
- low density lipoprotein cholesterol measurement · score 0.26
- phospholipid measurement · score 0.21
- phosphatidylcholine measurement · score 0.18
- lung adenocarcinoma · score 0.11
- cutaneous melanoma · score 0.11
- esophageal cancer · score 0.10
- squamous cell lung carcinoma · score 0.10
- MODY · score 0.05
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54315-F1 | alphafold | PREDICTED | 94.53 | — |
Amino-acid sequence (467 residues)
MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE KIGTRFLLYT NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG DESWVTDMCK KLFEVEEVNC ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM LDILLTEYSY PPSKVHLIGH SLGAHVAGEA GSKTPGLSRI TGLDPVEASF ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG HLDFFPNGGE SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA SNFARWRYGV SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH SYEFDAKLDV GTIEKVKFLW NNNVINPTLP KVGATKITVQ KGEEKTVYNF CSEDTVREDT LLTLTPC
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