About Tyrosine--tRNA ligase, cytoplasmic
Tyrosine--tRNA ligase, cytoplasmic (YARS1) is a protein
from Homo sapiens identified by UniProt accession
P54577, 528 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Tyrosine--tRNA ligase, cytoplasmic |
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| UniProt accession | P54577 |
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| Gene | YARS1 |
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| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (84)
Diseases linked to this target (Open Targets).
- neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2 · score 0.67
- Charcot-Marie-Tooth disease dominant intermediate C · score 0.67
- Autosomal dominant intermediate Charcot-Marie-Tooth disease type C · score 0.60
- genetic disorder · score 0.51
- Charcot-Marie-Tooth disease · score 0.41
- Neurodevelopmental delay · score 0.33
- neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset · score 0.33
- body mass index · score 0.28
- Primary amenorrhea · score 0.26
- retinal degeneration · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
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| AF-P54577-F1 | alphafold | PREDICTED | 90.80 | — |
Amino-acid sequence (528 residues)
MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS
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