Ubiquitin carboxyl-terminal hydrolase 14 (USP14)

About Ubiquitin carboxyl-terminal hydrolase 14

Ubiquitin carboxyl-terminal hydrolase 14 (USP14) is a protein from Homo sapiens identified by UniProt accession P54578, 494 residues long. MolForge cross-references it against 0 known binders and 281 disease associations.

Target properties

Protein name	Ubiquitin carboxyl-terminal hydrolase 14
UniProt accession	P54578
Gene	USP14
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (281)

Diseases linked to this target (Open Targets).

vital capacity · score 0.35
brain measurement · score 0.30
age at menarche · score 0.28
triglyceride measurement · score 0.24
low grade glioma · score 0.23
ovarian cancer · score 0.23
high density lipoprotein cholesterol measurement · score 0.20
body height · score 0.17
smoking status measurement · score 0.15
smoking behavior · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54578-F1	alphafold	PREDICTED	81.92	—

Amino-acid sequence (494 residues)

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH MAFPQFAEKG EQGQYLQQDA NECWIQMMRV LQQKLEAIED DSVKETDSSS ASAATPSKKK SLIDQFFGVE FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDMYELCT PELQEKMVSF RSKFKDLEDK KVNQQPNTSD KKSSPQKEVK YEPFSFADDI GSNNCGYYDL QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF DDDKVSIVTP EDILRLSGGG DWHIAYVLLY GPRRVEIMEE ESEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards