About 5'-AMP-activated protein kinase subunit gamma-1
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) is a protein
from Homo sapiens identified by UniProt accession
P54619, 331 residues long.
MolForge cross-references it against 0 known binders and
386 disease associations.
Target properties
| Protein name | 5'-AMP-activated protein kinase subunit gamma-1 |
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| UniProt accession | P54619 |
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| Gene | PRKAG1 |
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| Organism | Homo sapiens |
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| Length | 331 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (386)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.26
- head and neck squamous cell carcinoma · score 0.24
- Red cell distribution width · score 0.19
- systolic blood pressure · score 0.19
- esophageal cancer · score 0.19
- intelligence · score 0.18
- mathematical ability · score 0.17
- sex hormone-binding globulin measurement · score 0.16
- pulse pressure measurement · score 0.15
- diastolic blood pressure · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54619-F1 | alphafold | PREDICTED | 86.58 | — |
Amino-acid sequence (331 residues)
METVISSDSS PAVENEHPQE TPESNNSVYT SFMKSHRCYD LIPTSSKLVV FDTSLQVKKA FFALVTNGVR AAPLWDSKKQ SFVGMLTITD FINILHRYYK SALVQIYELE EHKIETWREV YLQDSFKPLV CISPNASLFD AVSSLIRNKI HRLPVIDPES GNTLYILTHK RILKFLKLFI TEFPKPEFMS KSLEELQIGT YANIAMVRTT TPVYVALGIF VQHRVSALPV VDEKGRVVDI YSKFDVINLA AEKTYNNLDV SVTKALQHRS HYFEGVLKCY LHETLETIIN RLVEAEVHRL VVVDENDVVK GIVSLSDILQ ALVLTGGEKK P
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