About 5'-AMP-activated protein kinase catalytic subunit alpha-2
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) is a protein
from Homo sapiens identified by UniProt accession
P54646, 552 residues long.
MolForge cross-references it against 0 known binders and
428 disease associations.
Target properties
| Protein name | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| UniProt accession | P54646 |
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| Gene | PRKAA2 |
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| Organism | Homo sapiens |
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| Length | 552 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (428)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.37
- protein measurement · score 0.33
- systolic blood pressure · score 0.31
- reticulocyte count · score 0.29
- cardiovascular disease · score 0.29
- breast adenocarcinoma · score 0.29
- monocyte count · score 0.29
- myeloid white cell count · score 0.26
- acute myeloid leukemia · score 0.26
- ovarian cancer · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54646-F1 | alphafold | PREDICTED | 76.67 | — |
Amino-acid sequence (552 residues)
MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ KIRSLDVVGK IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE LFDYICKHGR VEEMEARRLF QQILSAVDYC HRHMVVHRDL KPENVLLDAH MNAKIADFGL SNMMSDGEFL RTSCGSPNYA APEVISGRLY AGPEVDIWSC GVILYALLCG TLPFDDEHVP TLFKKIRGGV FYIPEYLNRS VATLLMHMLQ VDPLKRATIK DIREHEWFKQ DLPSYLFPED PSYDANVIDD EAVKEVCEKF ECTESEVMNS LYSGDPQDQL AVAYHLIIDN RRIMNQASEF YLASSPPSGS FMDDSAMHIP PGLKPHPERM PPLIADSPKA RCPLDALNTT KPKSLAVKKA KWHLGIRSQS KPYDIMAEVY RAMKQLDFEW KVVNAYHLRV RRKNPVTGNY VKMSLQLYLV DNRSYLLDFK SIDDEVVEQR SGSSTPQRSC SAAGLHRPRS SFDSTTAESH SLSGSLTGSL TGSTLSSVSP RLGSHTMDFF EMCASLITTL AR
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