About Heat shock-related 70 kDa protein 2
Heat shock-related 70 kDa protein 2 (HSPA2) is a protein
from Homo sapiens identified by UniProt accession
P54652, 639 residues long.
MolForge cross-references it against 0 known binders and
221 disease associations.
Target properties
| Protein name | Heat shock-related 70 kDa protein 2 |
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| UniProt accession | P54652 |
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| Gene | HSPA2 |
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| Organism | Homo sapiens |
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| Length | 639 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (221)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.24
- body height · score 0.19
- heel bone mineral density · score 0.17
- cup-to-disc ratio measurement · score 0.16
- mean corpuscular hemoglobin · score 0.15
- Red cell distribution width · score 0.14
- optic disc size measurement · score 0.14
- optic disc area measurement · score 0.13
- optic cup area measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54652-F1 | alphafold | PREDICTED | 88.79 | — |
Amino-acid sequence (639 residues)
MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG KPKVQVEYKG ETKTFFPEEI SSMVLTKMKE IAEAYLGGKV HSAVITVPAY FNDSQRQATK DAGTITGLNV LRIINEPTAA AIAYGLDKKG CAGGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM VSHLAEEFKR KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT PLSLGIETAG GVMTPLIKRN TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT FDIDANGILN VTAADKSTGK ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA AKNALESYTY NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK ELERVCNPII SKLYQGGPGG GSGGGGSGAS GGPTIEEVD
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