About Branched-chain-amino-acid aminotransferase, cytosolic
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) is a protein
from Homo sapiens identified by UniProt accession
P54687, 386 residues long.
MolForge cross-references it against 0 known binders and
194 disease associations.
Target properties
| Protein name | Branched-chain-amino-acid aminotransferase, cytosolic |
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| UniProt accession | P54687 |
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| Gene | BCAT1 |
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| Organism | Homo sapiens |
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| Length | 386 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (194)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.31
- neurofibrillary tangles measurement · score 0.30
- hair colour measurement · score 0.12
- hepatocellular carcinoma · score 0.10
- cancer · score 0.10
- neoplasm · score 0.09
- diet measurement · score 0.09
- esophageal squamous cell carcinoma · score 0.09
- head and neck squamous cell carcinoma · score 0.08
- metabolite measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54687-F1 | alphafold | PREDICTED | 94.45 | — |
Amino-acid sequence (386 residues)
MKDCSNGCSA ECTGEGGSKE VVGTFKAKDL IVTPATILKE KPDPNNLVFG TVFTDHMLTV EWSSEFGWEK PHIKPLQNLS LHPGSSALHY AVELFEGLKA FRGVDNKIRL FQPNLNMDRM YRSAVRATLP VFDKEELLEC IQQLVKLDQE WVPYSTSASL YIRPTFIGTE PSLGVKKPTK ALLFVLLSPV GPYFSSGTFN PVSLWANPKY VRAWKGGTGD CKMGGNYGSS LFAQCEAVDN GCQQVLWLYG EDHQITEVGT MNLFLYWINE DGEEELATPP LDGIILPGVT RRCILDLAHQ WGEFKVSERY LTMDDLTTAL EGNRVREMFG SGTACVVCPV SDILYKGETI HIPTMENGPK LASRILSKLT DIQYGREESD WTIVLS
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