Sodium/potassium-transporting ATPase subunit gamma…

About Sodium/potassium-transporting ATPase subunit gamma

Sodium/potassium-transporting ATPase subunit gamma (FXYD2) is a protein from Homo sapiens identified by UniProt accession P54710, 66 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Sodium/potassium-transporting ATPase subunit gamma
UniProt accession	P54710
Gene	FXYD2
Organism	Homo sapiens
Length	66 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

renal hypomagnesemia 2 · score 0.52
Autosomal dominant primary hypomagnesemia with hypocalciuria · score 0.48
neurodegenerative disease · score 0.41
type 2 diabetes mellitus · score 0.27
neuroinflammatory disorder · score 0.23
Myopia · score 0.20
urate measurement · score 0.19
age at onset · score 0.15
genetic disorder · score 0.15
refractive error · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54710-F1	alphafold	PREDICTED	75.63	—

Amino-acid sequence (66 residues)

MTGLSMDGGG SPKGDVDPFY YDYETVRNGG LIFAGLAFIV GLLILLSRRF RCGGNKKRRQ INEDEP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Sodium/potassium-transporting ATPase subunit gamma (FXYD2)