Lysine-specific demethylase RAD23B (RAD23B)

About Lysine-specific demethylase RAD23B

Lysine-specific demethylase RAD23B (RAD23B) is a protein from Homo sapiens identified by UniProt accession P54727, 409 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Lysine-specific demethylase RAD23B
UniProt accession	P54727
Gene	RAD23B
Organism	Homo sapiens
Length	409 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

cortical surface area measurement · score 0.38
cortical thickness · score 0.36
brain measurement · score 0.30
neuroimaging measurement · score 0.29
prostate carcinoma · score 0.28
IGF-1 measurement · score 0.27
reticulocyte count · score 0.25
breast adenocarcinoma · score 0.23
FEV/FVC ratio · score 0.20
glioblastoma multiforme · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54727-F1	alphafold	PREDICTED	67.35	—

Amino-acid sequence (409 residues)

MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT STPASITPAS ATASSEPAPA SAAKQEKPAE KPAETPVATS PTATDSTSGD SSRSNLFEDA TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD PPQAASTGAP QSSAVAAAAA TTTATTTTTS SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGGQGG GGGGGSGGIA EAGSGHMNYI QVTPQEKEAI ERLKALGFPE GLVIQAYFAC EKNENLAANF LLQQNFDED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards