About Alpha-N-acetylglucosaminidase
Alpha-N-acetylglucosaminidase (NAGLU) is a protein
from Homo sapiens identified by UniProt accession
P54802, 743 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Alpha-N-acetylglucosaminidase |
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| UniProt accession | P54802 |
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| Gene | NAGLU |
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| Organism | Homo sapiens |
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| Length | 743 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (127)
Diseases linked to this target (Open Targets).
- mucopolysaccharidosis type 3B · score 0.88
- Charcot-Marie-Tooth disease axonal type 2V · score 0.71
- mucopolysaccharidosis type 3 · score 0.68
- genetic disorder · score 0.51
- Abnormality of metabolism/homeostasis · score 0.45
- Hepatosplenomegaly · score 0.43
- Abnormal facial shape · score 0.43
- Intellectual disability, severe · score 0.43
- Coarse facial features · score 0.43
- hypertrichosis · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54802-F1 | alphafold | PREDICTED | 96.73 | — |
Amino-acid sequence (743 residues)
MEAVAVAAAV GVLLLAGAGG AAGDEAREAA AVRALVARLL GPGPAADFSV SVERALAAKP GLDTYSLGGG GAARVRVRGS TGVAAAAGLH RYLRDFCGCH VAWSGSQLRL PRPLPAVPGE LTEATPNRYR YYQNVCTQSY SFVWWDWARW EREIDWMALN GINLALAWSG QEAIWQRVYL ALGLTQAEIN EFFTGPAFLA WGRMGNLHTW DGPLPPSWHI KQLYLQHRVL DQMRSFGMTP VLPAFAGHVP EAVTRVFPQV NVTKMGSWGH FNCSYSCSFL LAPEDPIFPI IGSLFLRELI KEFGTDHIYG ADTFNEMQPP SSEPSYLAAA TTAVYEAMTA VDTEAVWLLQ GWLFQHQPQF WGPAQIRAVL GAVPRGRLLV LDLFAESQPV YTRTASFQGQ PFIWCMLHNF GGNHGLFGAL EAVNGGPEAA RLFPNSTMVG TGMAPEGISQ NEVVYSLMAE LGWRKDPVPD LAAWVTSFAA RRYGVSHPDA GAAWRLLLRS VYNCSGEACR GHNRSPLVRR PSLQMNTSIW YNRSDVFEAW RLLLTSAPSL ATSPAFRYDL LDLTRQAVQE LVSLYYEEAR SAYLSKELAS LLRAGGVLAY ELLPALDEVL ASDSRFLLGS WLEQARAAAV SEAEADFYEQ NSRYQLTLWG PEGNILDYAN KQLAGLVANY YTPRWRLFLE ALVDSVAQGI PFQQHQFDKN VFQLEQAFVL SKQRYPSQPR GDTVDLAKKI FLKYYPRWVA GSW
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