About Galactocerebrosidase
Galactocerebrosidase (GALC) is a protein
from Homo sapiens identified by UniProt accession
P54803, 685 residues long.
MolForge cross-references it against 0 known binders and
538 disease associations.
Target properties
| Protein name | Galactocerebrosidase |
|---|
| UniProt accession | P54803 |
|---|
| Gene | GALC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 685 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (538)
Diseases linked to this target (Open Targets).
- Krabbe disease · score 0.86
- genetic disorder · score 0.51
- body mass index · score 0.51
- basophil count · score 0.42
- inflammatory bowel disease · score 0.42
- spastic ataxia · score 0.41
- Crohn's disease · score 0.38
- adult Krabbe disease · score 0.38
- infantile Krabbe disease · score 0.37
- late-infantile/juvenile Krabbe disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54803-F1 | alphafold | PREDICTED | 94.14 | — |
Amino-acid sequence (685 residues)
MAEWLLSASW QRRAKAMTAA AGSAGRAAVP LLLCALLAPG GAYVLDDSDG LGREFDGIGA VSGGGATSRL LVNYPEPYRS QILDYLFKPN FGASLHILKV EIGGDGQTTD GTEPSHMHYA LDENYFRGYE WWLMKEAKKR NPNITLIGLP WSFPGWLGKG FDWPYVNLQL TAYYVVTWIV GAKRYHDLDI DYIGIWNERS YNANYIKILR KMLNYQGLQR VKIIASDNLW ESISASMLLD AELFKVVDVI GAHYPGTHSA KDAKLTGKKL WSSEDFSTLN SDMGAGCWGR ILNQNYINGY MTSTIAWNLV ASYYEQLPYG RCGLMTAQEP WSGHYVVESP VWVSAHTTQF TQPGWYYLKT VGHLEKGGSY VALTDGLGNL TIIIETMSHK HSKCIRPFLP YFNVSQQFAT FVLKGSFSEI PELQVWYTKL GKTSERFLFK QLDSLWLLDS DGSFTLSLHE DELFTLTTLT TGRKGSYPLP PKSQPFPSTY KDDFNVDYPF FSEAPNFADQ TGVFEYFTNI EDPGEHHFTL RQVLNQRPIT WAADASNTIS IIGDYNWTNL TIKCDVYIET PDTGGVFIAG RVNKGGILIR SARGIFFWIF ANGSYRVTGD LAGWIIYALG RVEVTAKKWY TLTLTIKGHF TSGMLNDKSL WTDIPVNFPK NGWAAIGTHS FEFAQFDNFL VEATR
Explore Galactocerebrosidase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets