About Adenylate kinase 2, mitochondrial
Adenylate kinase 2, mitochondrial (AK2) is a protein
from Homo sapiens identified by UniProt accession
P54819, 239 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Adenylate kinase 2, mitochondrial |
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| UniProt accession | P54819 |
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| Gene | AK2 |
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| Organism | Homo sapiens |
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| Length | 239 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (74)
Diseases linked to this target (Open Targets).
- reticular dysgenesis · score 0.81
- neurodegenerative disease · score 0.51
- severe combined immunodeficiency · score 0.47
- gut microbiome measurement · score 0.19
- genetic disorder · score 0.18
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.07
- cancer · score 0.05
- lung adenocarcinoma · score 0.04
- combined oxidative phosphorylation deficiency 46 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54819-F1 | alphafold | PREDICTED | 90.33 | — |
Amino-acid sequence (239 residues)
MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR SYHEEFNPPK EPMKDDITGE PLIRRSDDNE KALKIRLQAY HTQTTPLIEY YRKRGIHSAI DASQTPDVVF ASILAAFSKA TCKDLVMFI
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