Paired mesoderm homeobox protein 1 (PRRX1)

About Paired mesoderm homeobox protein 1

Paired mesoderm homeobox protein 1 (PRRX1) is a protein from Homo sapiens identified by UniProt accession P54821, 245 residues long. MolForge cross-references it against 0 known binders and 483 disease associations.

Target properties

Protein name	Paired mesoderm homeobox protein 1
UniProt accession	P54821
Gene	PRRX1
Organism	Homo sapiens
Length	245 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (483)

Diseases linked to this target (Open Targets).

agnathia-otocephaly complex · score 0.67
Agnathia - holoprosencephaly - situs inversus · score 0.58
atrial fibrillation · score 0.47
heel bone mineral density · score 0.47
body height · score 0.47
craniosynostosis · score 0.43
bone quantitative ultrasound measurement · score 0.42
glomerular filtration rate · score 0.40
BMI-adjusted hip circumference · score 0.39
body fat percentage · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54821-F1	alphafold	PREDICTED	64.85	—

Amino-acid sequence (245 residues)

MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADENVGEA GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ VPTVN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards