Growth arrest-specific protein 1 (GAS1)

About Growth arrest-specific protein 1

Growth arrest-specific protein 1 (GAS1) is a protein from Homo sapiens identified by UniProt accession P54826, 345 residues long. MolForge cross-references it against 0 known binders and 402 disease associations.

Target properties

Protein name	Growth arrest-specific protein 1
UniProt accession	P54826
Gene	GAS1
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (402)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
alobar holoprosencephaly · score 0.37
microform holoprosencephaly · score 0.37
lobar holoprosencephaly · score 0.37
midline interhemispheric variant of holoprosencephaly · score 0.37
semilobar holoprosencephaly · score 0.37
septopreoptic holoprosencephaly · score 0.37
heel bone mineral density · score 0.37
Red cell distribution width · score 0.31
cortical surface area measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54826-F1	alphafold	PREDICTED	69.77	—

Amino-acid sequence (345 residues)

MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards