About Tyrosine-protein phosphatase non-receptor type 5
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) is a protein
from Homo sapiens identified by UniProt accession
P54829, 565 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 5 |
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| UniProt accession | P54829 |
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| Gene | PTPN5 |
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| Organism | Homo sapiens |
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| Length | 565 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- Myopia · score 0.17
- refractive error · score 0.17
- Abnormality of refraction · score 0.16
- breast cancer · score 0.07
- glioblastoma multiforme · score 0.04
- central nervous system cancer · score 0.03
- ependymoma · score 0.03
- myopia · score 0.03
- gastric adenocarcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54829-F1 | alphafold | PREDICTED | 72.03 | — |
Amino-acid sequence (565 residues)
MNYEGARSER ENHAADDSEG GALDMCCSER LPGLPQPIVM EALDEAEGLQ DSQREMPPPP PPSPPSDPAQ KPPPRGAGSH SLTVRSSLCL FAASQFLLAC GVLWFSGYGH IWSQNATNLV SSLLTLLKQL EPTAWLDSGT WGVPSLLLVF LSVGLVLVTT LVWHLLRTPP EPPTPLPPED RRQSVSRQPS FTYSEWMEEK IEDDFLDLDP VPETPVFDCV MDIKPEADPT SLTVKSMGLQ ERRGSNVSLT LDMCTPGCNE EGFGYLMSPR EESAREYLLS ASRVLQAEEL HEKALDPFLL QAEFFEIPMN FVDPKEYDIP GLVRKNRYKT ILPNPHSRVC LTSPDPDDPL SSYINANYIR GYGGEEKVYI ATQGPIVSTV ADFWRMVWQE HTPIIVMITN IEEMNEKCTE YWPEEQVAYD GVEITVQKVI HTEDYRLRLI SLKSGTEERG LKHYWFTSWP DQKTPDRAPP LLHLVREVEE AAQQEGPHCA PIIVHCSAGI GRTGCFIATS ICCQQLRQEG VVDILKTTCQ LRQDRGGMIQ TCEQYQFVHH VMSLYEKQLS HQSPE
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