Neural retina-specific leucine zipper protein (NRL)

About Neural retina-specific leucine zipper protein

Neural retina-specific leucine zipper protein (NRL) is a protein from Homo sapiens identified by UniProt accession P54845, 237 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Neural retina-specific leucine zipper protein
UniProt accession	P54845
Gene	NRL
Organism	Homo sapiens
Length	237 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.69
phosphoenolpyruvate carboxykinase deficiency, mitochondrial · score 0.46
Retinal dystrophy · score 0.41
enhanced S-cone syndrome · score 0.34
self reported educational attainment · score 0.18
genetic disorder · score 0.18
smoking status measurement · score 0.14
cognitive function measurement · score 0.14
autosomal dominant retinitis pigmentosa · score 0.12
Abnormality of metabolism/homeostasis · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54845-F1	alphafold	PREDICTED	70.92	—

Amino-acid sequence (237 residues)

MALPPSPLAM EYVNDFDLMK FEVKREPSEG RPGPPTASLG STPYSSVPPS PTFSEPGMVG ATEGTRPGLE ELYWLATLQQ QLGAGEALGL SPEEAMELLQ GQGPVPVDGP HGYYPGSPEE TGAQHVQLAE RFSDAALVSM SVRELNRQLR GCGRDEALRL KQRRRTLKNR GYAQACRSKR LQQRRGLEAE RARLAAQLDA LRAEVARLAR ERDLYKARCD RLTSSGPGSG DPSHLFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards