About Hydroxymethylglutaryl-CoA synthase, mitochondrial
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2) is a protein
from Homo sapiens identified by UniProt accession
P54868, 508 residues long.
MolForge cross-references it against 0 known binders and
211 disease associations.
Target properties
| Protein name | Hydroxymethylglutaryl-CoA synthase, mitochondrial |
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| UniProt accession | P54868 |
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| Gene | HMGCS2 |
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| Organism | Homo sapiens |
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| Length | 508 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (211)
Diseases linked to this target (Open Targets).
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.84
- genetic disorder · score 0.41
- glucose measurement · score 0.27
- metabolite measurement · score 0.19
- hematocrit · score 0.14
- hemoglobin measurement · score 0.14
- erythrocyte count · score 0.13
- urate measurement · score 0.13
- macular telangiectasia type 2 · score 0.12
- acetone measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54868-F1 | alphafold | PREDICTED | 91.95 | — |
Amino-acid sequence (508 residues)
MQRLLTPVKR ILQLTRAVQE TSLTPARLLP VAHQRFSTAS AVPLAKTDTW PKDVGILALE VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERIQLP WDSVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM ESSSWDGRYA MVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLALERGL RGTHMENVYD FYKPNLASEY PIVDGKLSIQ CYLRALDRCY TSYRKKIQNQ WKQAGSDRPF TLDDLQYMIF HTPFCKMVQK SLARLMFNDF LSASSDTQTS LYKGLEAFGG LKLEDTYTNK DLDKALLKAS QDMFDKKTKA SLYLSTHNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF FSFRVSQDAA PGSPLDKLVS STSDLPKRLA SRKCVSPEEF TEIMNQREQF YHKVNFSPPG DTNSLFPGTW YLERVDEQHR RKYARRPV
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