About Delta-1-pyrroline-5-carboxylate synthase
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) is a protein
from Homo sapiens identified by UniProt accession
P54886, 795 residues long.
MolForge cross-references it against 0 known binders and
215 disease associations.
Target properties
| Protein name | Delta-1-pyrroline-5-carboxylate synthase |
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| UniProt accession | P54886 |
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| Gene | ALDH18A1 |
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| Organism | Homo sapiens |
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| Length | 795 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (215)
Diseases linked to this target (Open Targets).
- ALDH18A1-related de Barsy syndrome · score 0.83
- cutis laxa, autosomal dominant 3 · score 0.81
- autosomal recessive complex spastic paraplegia type 9B · score 0.79
- autosomal dominant spastic paraplegia type 9 · score 0.70
- de Barsy syndrome · score 0.57
- genetic disorder · score 0.47
- P5CS deficiency · score 0.44
- autosomal dominant cutis laxa · score 0.37
- hereditary spastic paraplegia · score 0.34
- Intellectual disability · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54886-F1 | alphafold | PREDICTED | 84.17 | — |
Amino-acid sequence (795 residues)
MLSQVYRCGF QPFNQHLLPW VKCTTVFRSH CIQPSVIRHV RSWSNIPFIT VPLSRTHGKS FAHRSELKHA KRIVVKLGSA VVTRGDECGL ALGRLASIVE QVSVLQNQGR EMMLVTSGAV AFGKQRLRHE ILLSQSVRQA LHSGQNQLKE MAIPVLEARA CAAAGQSGLM ALYEAMFTQY SICAAQILVT NLDFHDEQKR RNLNGTLHEL LRMNIVPIVN TNDAVVPPAE PNSDLQGVNV ISVKDNDSLA ARLAVEMKTD LLIVLSDVEG LFDSPPGSDD AKLIDIFYPG DQQSVTFGTK SRVGMGGMEA KVKAALWALQ GGTSVVIANG THPKVSGHVI TDIVEGKKVG TFFSEVKPAG PTVEQQGEMA RSGGRMLATL EPEQRAEIIH HLADLLTDQR DEILLANKKD LEEAEGRLAA PLLKRLSLST SKLNSLAIGL RQIAASSQDS VGRVLRRTRI AKNLELEQVT VPIGVLLVIF ESRPDCLPQV AALAIASGNG LLLKGGKEAA HSNRILHLLT QEALSIHGVK EAVQLVNTRE EVEDLCRLDK MIDLIIPRGS SQLVRDIQKA AKGIPVMGHS EGICHMYVDS EASVDKVTRL VRDSKCEYPA ACNALETLLI HRDLLRTPLF DQIIDMLRVE QVKIHAGPKF ASYLTFSPSE VKSLRTEYGD LELCIEVVDN VQDAIDHIHK YGSSHTDVIV TEDENTAEFF LQHVDSACVF WNASTRFSDG YRFGLGAEVG ISTSRIHARG PVGLEGLLTT KWLLRGKDHV VSDFSEHGSL KYLHENLPIP QRNTN
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