Alpha-soluble NSF attachment protein (NAPA)

About Alpha-soluble NSF attachment protein

Alpha-soluble NSF attachment protein (NAPA) is a protein from Homo sapiens identified by UniProt accession P54920, 295 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Alpha-soluble NSF attachment protein
UniProt accession	P54920
Gene	NAPA
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

gait measurement · score 0.16
gut microbiome measurement · score 0.14
brain measurement · score 0.12
sex hormone-binding globulin measurement · score 0.11
breast adenocarcinoma · score 0.10
lissencephaly due to TUBA1A mutation · score 0.05
Genetic central nervous system malformation · score 0.04
response to statin · score 0.04
Dandy-Walker syndrome · score 0.04
cobblestone lissencephaly without muscular or ocular involvement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P54920-F1	alphafold	PREDICTED	89.11	—

Amino-acid sequence (295 residues)

MDNSGKEAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN MFKMAKNWSA AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA INCLMRAIEI YTDMGRFTIA AKHHISIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAG YAALLEQYQK AIDIYEQVGT NAMDSPLLKY SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE CKLMKKLLEA HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards