Allograft inflammatory factor 1 (AIF1)

About Allograft inflammatory factor 1

Allograft inflammatory factor 1 (AIF1) is a protein from Homo sapiens identified by UniProt accession P55008, 147 residues long. MolForge cross-references it against 0 known binders and 640 disease associations.

Target properties

Protein name	Allograft inflammatory factor 1
UniProt accession	P55008
Gene	AIF1
Organism	Homo sapiens
Length	147 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (640)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
inflammatory bowel disease · score 0.17
body mass index · score 0.12
neutrophil collagenase measurement · score 0.11
experimental autoimmune encephalomyelitis · score 0.11
neoplasm · score 0.10
Spinal cord injury · score 0.10
cancer · score 0.09
Rheumatoid arthritis · score 0.09
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55008-F1	alphafold	PREDICTED	86.80	—

Amino-acid sequence (147 residues)

MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM ILMYEEKARE KEKPTGPPAK KAISELP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards