26S proteasome non-ATPase regulatory subunit 4 (PSMD4)

About 26S proteasome non-ATPase regulatory subunit 4

26S proteasome non-ATPase regulatory subunit 4 (PSMD4) is a protein from Homo sapiens identified by UniProt accession P55036, 377 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	26S proteasome non-ATPase regulatory subunit 4
UniProt accession	P55036
Gene	PSMD4
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
glioblastoma multiforme · score 0.30
breast adenocarcinoma · score 0.30
low grade glioma · score 0.29
endometrial cancer · score 0.29
lung adenocarcinoma · score 0.29
esophageal cancer · score 0.28
urinary bladder cancer · score 0.28
squamous cell lung carcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55036-F1	alphafold	PREDICTED	72.05	—

Amino-acid sequence (377 residues)

MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN EKDLVKLAKR LKKEKVNVDI INFGEEEVNT EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA DALISSPILA GEGGAMLGLG ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA ASAAEAGIAT TGTEDSDDAL LKMTISQQEF GRTGLPDLSS MTEEEQIAYA MQMSLQGAEF GQAESADIDA SSAMDTSEPA KEEDDYDVMQ DPEFLQSVLE NLPGVDPNNE AIRNAMGSLA SQATKDGKKD KKEEDKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards