Developmentally-regulated GTP-binding protein 2 (DRG2)

About Developmentally-regulated GTP-binding protein 2

Developmentally-regulated GTP-binding protein 2 (DRG2) is a protein from Homo sapiens identified by UniProt accession P55039, 364 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Developmentally-regulated GTP-binding protein 2
UniProt accession	P55039
Gene	DRG2
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.29
neurodegenerative disease · score 0.24
blood phosphate measurement · score 0.22
insulin like growth factor measurement · score 0.12
IGF-1 measurement · score 0.12
BMI-adjusted hip circumference · score 0.10
neoplasm · score 0.08
BMI-adjusted waist-hip ratio · score 0.07
cancer · score 0.07
melanoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55039-F1	alphafold	PREDICTED	84.71	—

Amino-acid sequence (364 residues)

MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII EGAAQGKGRG RQVIAVARTA DVIIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP CLYVYNKIDQ ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT HTMEHEDVIQ IVKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards