About GTP-binding protein GEM
GTP-binding protein GEM (GEM) is a protein
from Homo sapiens identified by UniProt accession
P55040, 296 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | GTP-binding protein GEM |
|---|
| UniProt accession | P55040 |
|---|
| Gene | GEM |
|---|
| Organism | Homo sapiens |
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| Length | 296 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.47
- pulse pressure measurement · score 0.41
- coronary artery disease · score 0.27
- alcohol drinking · score 0.23
- MODY · score 0.09
- diastolic blood pressure · score 0.07
- hypertension · score 0.07
- diabetes mellitus, transient neonatal, 2 · score 0.06
- type 1 diabetes mellitus · score 0.05
- type 2 diabetes mellitus · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55040-F1 | alphafold | PREDICTED | 72.63 | — |
Amino-acid sequence (296 residues)
MTLNNVTMRQ GTVGMQPQQQ RWSIPADGRH LMVQKEPHQY SHRNRHSATP EDHCRRSWSS DSTDSVISSE SGNTYYRVVL IGEQGVGKST LANIFAGVHD SMDSDCEVLG EDTYERTLMV DGESATIILL DMWENKGENE WLHDHCMQVG DAYLIVYSIT DRASFEKASE LRIQLRRARQ TEDIPIILVG NKSDLVRCRE VSVSEGRACA VVFDCKFIET SAAVQHNVKE LFEGIVRQVR LRRDSKEKNE RRLAYQKRKE SMPRKARRFW GKIVAKNNKN MAFKLKSKSC HDLSVL
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