About Oxysterols receptor LXR-beta
Oxysterols receptor LXR-beta (NR1H2) is a protein
from Homo sapiens identified by UniProt accession
P55055, 460 residues long.
MolForge cross-references it against 0 known binders and
184 disease associations.
Target properties
| Protein name | Oxysterols receptor LXR-beta |
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| UniProt accession | P55055 |
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| Gene | NR1H2 |
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| Organism | Homo sapiens |
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| Length | 460 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (184)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- multiple sclerosis · score 0.50
- Parkinson disease · score 0.50
- Alzheimer disease · score 0.50
- lysosomal storage disease · score 0.50
- cutaneous melanoma · score 0.19
- lung adenocarcinoma · score 0.18
- myoepithelial tumor · score 0.11
- squamous cell lung carcinoma · score 0.11
- glioblastoma multiforme · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55055-F1 | alphafold | PREDICTED | 80.27 | — |
Amino-acid sequence (460 residues)
MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQESQSQ SQSPVGPQGS SSSASGPGAS PGGSEAGSQG SGEGEGVQLT AAQELMIQQL VAAQLQCNKR SFSDQPKVTP WPLGADPQSR DARQQRFAHF TELAIISVQE IVDFAKQVPG FLQLGREDQI ALLKASTIEI MLLETARRYN HETECITFLK DFTYSKDDFH RAGLQVEFIN PIFEFSRAMR RLGLDDAEYA LLIAINIFSA DRPNVQEPGR VEALQQPYVE ALLSYTRIKR PQDQLRFPRM LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE
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