About Phospholipid transfer protein
Phospholipid transfer protein (PLTP) is a protein
from Homo sapiens identified by UniProt accession
P55058, 493 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Phospholipid transfer protein |
|---|
| UniProt accession | P55058 |
|---|
| Gene | PLTP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 493 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (239)
Diseases linked to this target (Open Targets).
- cholesteryl ester measurement · score 0.57
- concentration of large HDL particles measurement · score 0.57
- phospholipids in very large HDL measurement · score 0.55
- total lipids in very large HDL measurement · score 0.55
- phospholipids:total lipids ratio · score 0.54
- high density lipoprotein particle size measurement · score 0.54
- free cholesterol to total lipids in very large HDL percentage · score 0.54
- cholesterol in very large HDL measurement · score 0.54
- free cholesterol in large HDL measurement · score 0.53
- cholesterol in large HDL measurement · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55058-F1 | alphafold | PREDICTED | 89.04 | — |
Amino-acid sequence (493 residues)
MALFGALFLA LLAGAHAEFP GCKIRVTSKA LELVKQEGLR FLEQELETIT IPDLRGKEGH FYYNISEVKV TELQLTSSEL DFQPQQELML QITNASLGLR FRRQLLYWFF YDGGYINASA EGVSIRTGLE LSRDPAGRMK VSNVSCQASV SRMHAAFGGT FKKVYDFLST FITSGMRFLL NQQICPVLYH AGTVLLNSLL DTVPVRSSVD ELVGIDYSLM KDPVASTSNL DMDFRGAFFP LTERNWSLPN RAVEPQLQEE ERMVYVAFSE FFFDSAMESY FRAGALQLLL VGDKVPHDLD MLLRATYFGS IVLLSPAVID SPLKLELRVL APPRCTIKPS GTTISVTASV TIALVPPDQP EVQLSSMTMD ARLSAKMALR GKALRTQLDL RRFRIYSNHS ALESLALIPL QAPLKTMLQI GVMPMLNERT WRGVQIPLPE GINFVHEVVT NHAGFLTIGA DLHFAKGLRE VIEKNRPADV RASTAPTPST AAV
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