About Aquaporin-5
Aquaporin-5 (AQP5) is a protein
from Homo sapiens identified by UniProt accession
P55064, 265 residues long.
MolForge cross-references it against 0 known binders and
287 disease associations.
Target properties
| Protein name | Aquaporin-5 |
|---|
| UniProt accession | P55064 |
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| Gene | AQP5 |
|---|
| Organism | Homo sapiens |
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| Length | 265 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (287)
Diseases linked to this target (Open Targets).
- Non-epidermolytic palmoplantar keratoderma · score 0.73
- diffuse palmoplantar keratoderma · score 0.49
- Palmoplantar keratoderma · score 0.37
- diffuse nonepidermolytic palmoplantar keratoderma · score 0.37
- neoplasm · score 0.11
- asthma · score 0.10
- breast cancer · score 0.09
- hepatocellular carcinoma · score 0.09
- allergic rhinitis · score 0.09
- allergic disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55064-F1 | alphafold | PREDICTED | 94.31 | — |
Amino-acid sequence (265 residues)
MKKEVCSVAF LKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQIALAFG LAIGTLAQAL GPVSGGHINP AITLALLVGN QISLLRAFFY VAAQLVGAIA GAGILYGVAP LNARGNLAVN ALNNNTTQGQ AMVVELILTF QLALCIFAST DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS PAHWVFWVGP IVGAVLAAIL YFYLLFPNSL SLSERVAIIK GTYEPDEDWE EQREERKKTM ELTTR
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