About Thyroxine 5-deiodinase
Thyroxine 5-deiodinase (DIO3) is a protein
from Homo sapiens identified by UniProt accession
P55073, 304 residues long.
MolForge cross-references it against 0 known binders and
179 disease associations.
Target properties
| Protein name | Thyroxine 5-deiodinase |
|---|
| UniProt accession | P55073 |
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| Gene | DIO3 |
|---|
| Organism | Homo sapiens |
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| Length | 304 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (179)
Diseases linked to this target (Open Targets).
- balding measurement · score 0.36
- neurodegenerative disease · score 0.36
- gut microbiome measurement · score 0.34
- mathematical ability · score 0.32
- hair shape measurement · score 0.29
- self reported educational attainment · score 0.28
- thyroxine measurement · score 0.28
- pulse pressure measurement · score 0.28
- keratitis · score 0.25
- smoking status measurement · score 0.24
Amino-acid sequence (304 residues)
MPRQATSRLV VGEGEGSQGA SGPAATMLRS LLLHSLRLCA QTASCLVLFP RFLGTAFMLW LLDFLCIRKH FLGRRRRGQP EPEVELNSEG EEVPPDDPPI CVSDDNRLCT LASLKAVWHG QKLDFFKQAH EGGPAPNSEV VLPDGFQSQH ILDYAQGNRP LVLNFGSCTU PPFMARMSAF QRLVTKYQRD VDFLIIYIEE AHPSDGWVTT DSPYIIPQHR SLEDRVSAAR VLQQGAPGCA LVLDTMANSS SSAYGAYFER LYVIQSGTIM YQGGRGPDGY QVSELRTWLE RYDEQLHGAR PRRV
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