About Fibroblast growth factor 8
Fibroblast growth factor 8 (FGF8) is a protein
from Homo sapiens identified by UniProt accession
P55075, 233 residues long.
MolForge cross-references it against 0 known binders and
210 disease associations.
Target properties
| Protein name | Fibroblast growth factor 8 |
|---|
| UniProt accession | P55075 |
|---|
| Gene | FGF8 |
|---|
| Organism | Homo sapiens |
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| Length | 233 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (210)
Diseases linked to this target (Open Targets).
- hypogonadotropic hypogonadism 6 with or without anosmia · score 0.75
- Kallmann syndrome · score 0.61
- cancer · score 0.60
- bone development disease · score 0.60
- holoprosencephaly · score 0.58
- neurodegenerative disease · score 0.46
- semilobar holoprosencephaly · score 0.45
- acrocephalosyndactyly · score 0.37
- craniosynostosis · score 0.37
- hypogonadotropic hypogonadism · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55075-F1 | alphafold | PREDICTED | 81.05 | — |
Amino-acid sequence (233 residues)
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR
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