Microfibrillar-associated protein 1 (MFAP1)

About Microfibrillar-associated protein 1

Microfibrillar-associated protein 1 (MFAP1) is a protein from Homo sapiens identified by UniProt accession P55081, 439 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Microfibrillar-associated protein 1
UniProt accession	P55081
Gene	MFAP1
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.21
breast adenocarcinoma · score 0.18
endometrial cancer · score 0.14
head and neck squamous cell carcinoma · score 0.10
hemoglobin A1 measurement · score 0.05
type 2 diabetes mellitus · score 0.04
susceptibility to urinary tract infection measurement · score 0.02
blood protein measurement · score 0.02
high density lipoprotein cholesterol measurement · score 0.02
Marfan syndrome · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55081-F1	alphafold	PREDICTED	71.34	—

Amino-acid sequence (439 residues)

MSVPSALMKQ PPIQSTAGAV PVRNEKGEIS MEKVKVKRYV SGKRPDYAPM ESSDEEDEEF QFIKKAKEQE AEPEEQEEDS SSDPRLRRLQ NRISEDVEER LARHRKIVEP EVVGESDSEV EGDAWRMERE DSSEEEEEEI DDEEIERRRG MMRQRAQERK NEEMEVMEVE DEGRSGEESE SESEYEEYTD SEDEMEPRLK PVFIRKKDRV TVQEREAEAL KQKELEQEAK RMAEERRKYT LKIVEEETKK ELEENKRSLA ALDALNTDDE NDEEEYEAWK VRELKRIKRD REDREALEKE KAEIERMRNL TEEERRAELR ANGKVITNKA VKGKYKFLQK YYHRGAFFMD EDEEVYKRDF SAPTLEDHFN KTILPKVMQV KNFGRSGRTK YTHLVDQDTT SFDSAWGQES AQNTKFFKQK AAGVRDVFER PSAKKRKTT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards