About Microfibril-associated glycoprotein 4
Microfibril-associated glycoprotein 4 (MFAP4) is a protein
from Homo sapiens identified by UniProt accession
P55083, 255 residues long.
MolForge cross-references it against 0 known binders and
158 disease associations.
Target properties
| Protein name | Microfibril-associated glycoprotein 4 |
|---|
| UniProt accession | P55083 |
|---|
| Gene | MFAP4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (158)
Diseases linked to this target (Open Targets).
- Hernia · score 0.28
- lung adenocarcinoma · score 0.23
- skin aging · score 0.21
- endometrial cancer · score 0.14
- lymphocyte count · score 0.10
- head and neck squamous cell carcinoma · score 0.10
- diastolic blood pressure · score 0.08
- achalasia-alacrima syndrome · score 0.07
- atrial fibrillation · score 0.07
- non-alcoholic fatty liver disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55083-F1 | alphafold | PREDICTED | 90.42 | — |
Amino-acid sequence (255 residues)
MKALLALPLL LLLSTPPCAP QVSGIRGDAL ERFCLQQPLD CDDIYAQGYQ SDGVYLIYPS GPSVPVPVFC DMTTEGGKWT VFQKRFNGSV SFFRGWNDYK LGFGRADGEY WLGLQNMHLL TLKQKYELRV DLEDFENNTA YAKYADFSIS PNAVSAEEDG YTLFVAGFED GGAGDSLSYH SGQKFSTFDR DQDLFVQNCA ALSSGAFWFR SCHFANLNGF YLGGSHLSYA NGINWAQWKG FYYSLKRTEM KIRRA
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