About Trifunctional enzyme subunit beta, mitochondrial
Trifunctional enzyme subunit beta, mitochondrial (HADHB) is a protein
from Homo sapiens identified by UniProt accession
P55084, 474 residues long.
MolForge cross-references it against 0 known binders and
258 disease associations.
Target properties
| Protein name | Trifunctional enzyme subunit beta, mitochondrial |
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| UniProt accession | P55084 |
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| Gene | HADHB |
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| Organism | Homo sapiens |
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| Length | 474 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (258)
Diseases linked to this target (Open Targets).
- mitochondrial trifunctional protein deficiency · score 0.75
- long chain 3-hydroxyacyl-CoA dehydrogenase deficiency · score 0.49
- hypertrophic cardiomyopathy · score 0.39
- neurodegenerative disease · score 0.34
- genetic disorder · score 0.19
- breast adenocarcinoma · score 0.18
- metabolic acidosis · score 0.12
- rickets · score 0.12
- renal tubular acidosis · score 0.12
- Charcot-Marie-Tooth disease · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55084-F1 | alphafold | PREDICTED | 91.13 | — |
Amino-acid sequence (474 residues)
MTILTYPFKN LPTASKWALR FSIRPLSCSS QLRAAPAVQT KTKKTLAKPN IRNVVVVDGV RTPFLLSGTS YKDLMPHDLA RAALTGLLHR TSVPKEVVDY IIFGTVIQEV KTSNVAREAA LGAGFSDKTP AHTVTMACIS ANQAMTTGVG LIASGQCDVI VAGGVELMSD VPIRHSRKMR KLMLDLNKAK SMGQRLSLIS KFRFNFLAPE LPAVSEFSTS ETMGHSADRL AAAFAVSRLE QDEYALRSHS LAKKAQDEGL LSDVVPFKVP GKDTVTKDNG IRPSSLEQMA KLKPAFIKPY GTVTAANSSF LTDGASAMLI MAEEKALAMG YKPKAYLRDF MYVSQDPKDQ LLLGPTYATP KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE NYMGRKTKVG LPPLEKFNNW GGSLSLGHPF GATGCRLVMA AANRLRKEGG QYGLVAACAA GGQGHAMIVE AYPK
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