Proteinase-activated receptor 2 (F2RL1)

About Proteinase-activated receptor 2

Proteinase-activated receptor 2 (F2RL1) is a protein from Homo sapiens identified by UniProt accession P55085, 397 residues long. MolForge cross-references it against 0 known binders and 365 disease associations.

Target properties

Protein name	Proteinase-activated receptor 2
UniProt accession	P55085
Gene	F2RL1
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (365)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
calcium measurement · score 0.39
mean platelet volume · score 0.36
serum albumin measurement · score 0.29
serum gamma-glutamyl transferase measurement · score 0.29
glioblastoma multiforme · score 0.27
proteinase-activated receptor 1 measurement · score 0.23
monocyte count · score 0.20
head and neck squamous cell carcinoma · score 0.16
medulloblastoma · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55085-F1	alphafold	PREDICTED	82.08	—

Amino-acid sequence (397 residues)

MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG KGVTVETVFS VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF LFRTKKKHPA VIYMANLALA DLLSVIWFPL KIAYHIHGNN WIYGEALCNV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP MGHSRKKANI AIGISLAIWL LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF NYFLSLAIGV FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD FRDHAKNALL CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards