About Aquaporin-4
Aquaporin-4 (AQP4) is a protein
from Homo sapiens identified by UniProt accession
P55087, 323 residues long.
MolForge cross-references it against 0 known binders and
794 disease associations.
Target properties
| Protein name | Aquaporin-4 |
|---|
| UniProt accession | P55087 |
|---|
| Gene | AQP4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 323 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (794)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.41
- glomerular filtration rate · score 0.40
- hemoglobin measurement · score 0.39
- cystatin C measurement · score 0.37
- urate measurement · score 0.35
- serum urea measurement · score 0.35
- hematocrit · score 0.35
- blood urea nitrogen measurement · score 0.35
- breast carcinoma · score 0.32
- erythrocyte count · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55087-F1 | alphafold | PREDICTED | 81.04 | — |
Amino-acid sequence (323 residues)
MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA AQCLGAIIGA GILYLVTPPS VVGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG AVLAGGLYEY VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH VIDVDRGEEK KGKDQSGEVL SSV
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