Urocortin (UCN)

About Urocortin

Urocortin (UCN) is a protein from Homo sapiens identified by UniProt accession P55089, 124 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	Urocortin
UniProt accession	P55089
Gene	UCN
Organism	Homo sapiens
Length	124 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.26
mean corpuscular hemoglobin concentration · score 0.05
deafness · score 0.05
endometriosis · score 0.04
familial glucocorticoid deficiency · score 0.04
heart disease · score 0.04
neoplasm · score 0.04
menstrual cycle-dependent periodic fever · score 0.03
cardiovascular disease · score 0.03
pigmented nodular adrenocortical disease, primary, 3 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55089-F1	alphafold	PREDICTED	68.26	—

Amino-acid sequence (124 residues)

MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL ELARTQSQRE RAEQNRIIFD SVGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards