Growth/differentiation factor 10 (GDF10)

About Growth/differentiation factor 10

Growth/differentiation factor 10 (GDF10) is a protein from Homo sapiens identified by UniProt accession P55107, 478 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Growth/differentiation factor 10
UniProt accession	P55107
Gene	GDF10
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.29
cortical surface area measurement · score 0.25
cortical thickness · score 0.25
pulse pressure measurement · score 0.23
brain measurement · score 0.20
neurodegenerative disease · score 0.19
mean arterial pressure · score 0.19
nose morphology measurement · score 0.18
prostate carcinoma · score 0.11
prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55107-F1	alphafold	PREDICTED	67.19	—

Amino-acid sequence (478 residues)

MAHVPARTSP GPGPQLLLLL LPLFLLLLRD VAGSHRAPAW SALPAAADGL QGDRDLQRHP GDAAATLGPS AQDMVAVHMH RLYEKYSRQG ARPGGGNTVR SFRARLEVVD QKAVYFFNLT SMQDSEMILT ATFHFYSEPP RWPRALEVLC KPRAKNASGR PLPLGPPTRQ HLLFRSLSQN TATQGLLRGA MALAPPPRGL WQAKDISPIV KAARRDGELL LSAQLDSEER DPGVPRPSPY APYILVYAND LAISEPNSVA VTLQRYDPFP AGDPEPRAAP NNSADPRVRR AAQATGPLQD NELPGLDERP PRAHAQHFHK HQLWPSPFRA LKPRPGRKDR RKKGQEVFMA ASQVLDFDEK TMQKARRKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF DAYYCAGACE FPMPKIVRPS NHATIQSIVR AVGIIPGIPE PCCVPDKMNS LGVLFLDENR NVVLKVYPNM SVDTCACR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards