About Mesencephalic astrocyte-derived neurotrophic factor
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein
from Homo sapiens identified by UniProt accession
P55145, 182 residues long.
MolForge cross-references it against 0 known binders and
208 disease associations.
Target properties
| Protein name | Mesencephalic astrocyte-derived neurotrophic factor |
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| UniProt accession | P55145 |
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| Gene | MANF |
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| Organism | Homo sapiens |
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| Length | 182 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (208)
Diseases linked to this target (Open Targets).
- diabetes, deafness, developmental delay, and short stature syndrome · score 0.51
- neurodegenerative disease · score 0.49
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.14
- hepatocellular carcinoma · score 0.10
- Stroke · score 0.09
- body mass index · score 0.09
- blood protein measurement · score 0.09
- major depressive disorder · score 0.08
- age at first facial hair · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55145-F1 | alphafold | PREDICTED | 81.69 | — |
Amino-acid sequence (182 residues)
MRRMWATQGL AVALALSVLP GSRALRPGDC EVCISYLGRF YQDLKDRDVT FSPATIENEL IKFCREARGK ENRLCYYIGA TDDAATKIIN EVSKPLAHHI PVEKICEKLK KKDSQICELK YDKQIDLSTV DLKKLRVKEL KKILDDWGET CKGCAEKSDY IRKINELMPK YAPKAASART DL
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