About RNA polymerase II elongation factor ELL
RNA polymerase II elongation factor ELL (ELL) is a protein
from Homo sapiens identified by UniProt accession
P55199, 621 residues long.
MolForge cross-references it against 0 known binders and
216 disease associations.
Target properties
| Protein name | RNA polymerase II elongation factor ELL |
|---|
| UniProt accession | P55199 |
|---|
| Gene | ELL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 621 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (216)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.58
- carcinoma of liver and intrahepatic biliary tract · score 0.37
- lung carcinoma · score 0.37
- bile duct carcinoma · score 0.37
- skin carcinoma · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- kidney neoplasm · score 0.37
- esophageal adenocarcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
- acute myeloid leukemia · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55199-F1 | alphafold | PREDICTED | 67.64 | — |
Amino-acid sequence (621 residues)
MAALKEDRSY GLSCGRVSDG SKVSVFHVKL TDSALRAFES YRARQDSVSL RPSIRFQGSQ GHISIPQPDC PAEARTFSFY LSNIGRDNPQ GSFDCIQQYV SSHGEVHLDC LGSIQDKITV CATDDSYQKA RQSMAQAEEE TRSRSAIVIK AGGRYLGKKV QFRKPAPGAT DAVPSRKRAT PINLASAIRK SGASAVSGGS GVSQRPFRDR VLHLLALRPY RKAELLLRLQ KDGLTQADKD ALDGLLQQVA NMSAKDGTCT LQDCMYKDVQ KDWPGYSEGD QQLLKRVLVR KLCQPQSTGS LLGDPAASSP PGERGRSASP PQKRLQPPDF IDPLANKKPR ISHFTQRAQP AVNGKLGVPN GREALLPTPG PPASTDTLSS STHLPPRLEP PRAHDPLADV SNDLGHSGRD CEHGEAAAPA PTVRLGLPLL TDCAQPSRPH GSPSRSKPKK KSKKHKDKER AAEDKPRAQL PDCAPATHAT PGAPADTPGL NGTCSVSSVP TSTSETPDYL LKYAAISSSE QRQSYKNDFN AEYSEYRDLH ARIERITRRF TQLDAQLRQL SQGSEEYETT RGQILQEYRK IKKTNTNYSQ EKHRCEYLHS KLAHIKRLIA EYDQRQLQAW P
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