Caspase-9 (CASP9)

About Caspase-9

Caspase-9 (CASP9) is a protein from Homo sapiens identified by UniProt accession P55211, 416 residues long. MolForge cross-references it against 0 known binders and 546 disease associations.

Target properties

Protein name	Caspase-9
UniProt accession	P55211
Gene	CASP9
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (546)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
glioblastoma multiforme · score 0.29
ovarian cancer · score 0.28
lung adenocarcinoma · score 0.28
squamous cell lung carcinoma · score 0.23
urate measurement · score 0.23
esophageal cancer · score 0.23
cutaneous melanoma · score 0.22
glomerular filtration rate · score 0.22
creatinine measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55211-F1	alphafold	PREDICTED	80.32	—

Amino-acid sequence (416 residues)

MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS RRDQARQLII DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK PTLENLTPVV LRPEIRKPEV LRPETPRPVD IGSGGFGDVG ALESLRGNAD LAYILSMEPC GHCLIINNVN FCRESGLRTR TGSNIDCEKL RRRFSSLHFM VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ ASHLQFPGAV YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG FVSWRDPKSG SWYVETLDDI FEQWAHSEDL QSLLLRVANA VSVKGIYKQM PGCFNFLRKK LFFKTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards