About Caspase-6
Caspase-6 (CASP6) is a protein
from Homo sapiens identified by UniProt accession
P55212, 293 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | Caspase-6 |
|---|
| UniProt accession | P55212 |
|---|
| Gene | CASP6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 293 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (219)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.27
- ovarian cancer · score 0.26
- endometrial cancer · score 0.26
- head and neck squamous cell carcinoma · score 0.25
- gastric adenocarcinoma · score 0.25
- PHF-tau measurement · score 0.24
- lung adenocarcinoma · score 0.24
- urinary bladder cancer · score 0.23
- cutaneous melanoma · score 0.14
- cirrhosis of liver · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55212-F1 | alphafold | PREDICTED | 84.89 | — |
Amino-acid sequence (293 residues)
MSSASGLRRG HPAGGEENMT ETDAFYKREM FDPAEKYKMD HRRRGIALIF NHERFFWHLT LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI HEVSTVSHAD ADCFVCVFLS HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS LVGKPKIFII QACRGNQHDV PVIPLDVVDN QTEKLDTNIT EVDAASVYTL PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKYG SSLEFTELLT LVNRKVSQRR VDFCKDPSAI GKKQVPCFAS MLTKKLHFFP KSN
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