About Pancreatic secretory granule membrane major glycoprotein GP2
Pancreatic secretory granule membrane major glycoprotein GP2 (GP2) is a protein
from Homo sapiens identified by UniProt accession
P55259, 537 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Pancreatic secretory granule membrane major glycoprotein GP2 |
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| UniProt accession | P55259 |
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| Gene | GP2 |
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| Organism | Homo sapiens |
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| Length | 537 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (164)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.47
- body mass index · score 0.45
- Drugs used in diabetes use measurement · score 0.38
- lean body mass · score 0.37
- fat body mass · score 0.33
- body weight · score 0.33
- insulin sensitivity measurement · score 0.31
- whole body water mass · score 0.24
- base metabolic rate measurement · score 0.24
- sleep quality · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55259-F1 | alphafold | PREDICTED | 78.59 | — |
Amino-acid sequence (537 residues)
MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS QVRSEVPAID LARVLDLGPI TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF
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