Cyclin-dependent kinase 4 inhibitor D (CDKN2D)

About Cyclin-dependent kinase 4 inhibitor D

Cyclin-dependent kinase 4 inhibitor D (CDKN2D) is a protein from Homo sapiens identified by UniProt accession P55273, 166 residues long. MolForge cross-references it against 0 known binders and 251 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 4 inhibitor D
UniProt accession	P55273
Gene	CDKN2D
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (251)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
Red cell distribution width · score 0.30
mean corpuscular volume · score 0.28
Parkinson disease · score 0.28
multiple sclerosis · score 0.28
lysosomal storage disease · score 0.28
Alzheimer disease · score 0.28
endometrial cancer · score 0.27
ovarian cancer · score 0.25
lung adenocarcinoma · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55273-F1	alphafold	PREDICTED	95.97	—

Amino-acid sequence (166 residues)

MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM FGSTAIALEL LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV NVPDGTGALP IHLAVQEGHT AVVSFLAAES DLHRRDARGL TPLELALQRG AQDLVDILQG HMVAPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards