About Cadherin-12
Cadherin-12 (CDH12) is a protein
from Homo sapiens identified by UniProt accession
P55289, 794 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Cadherin-12 |
|---|
| UniProt accession | P55289 |
|---|
| Gene | CDH12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 794 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- smoking initiation · score 0.35
- smoking status measurement · score 0.29
- protein measurement · score 0.28
- visual perception measurement · score 0.28
- gut microbiome measurement · score 0.27
- angina pectoris · score 0.26
- physical activity · score 0.26
- body mass index · score 0.26
- breast adenocarcinoma · score 0.26
- endometrial cancer · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55289-F1 | alphafold | PREDICTED | 77.31 | — |
Amino-acid sequence (794 residues)
MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ RVKRGWVWNQ FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPKF LDGPYVATVP EMSPVGAYVL QVKATDADDP TYGNSARVVY SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDGNEGT IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL PRQRPPMEDN TDIRDFIHQR LQENDVDPTA PPYDSLATYA YEGSGSVAES LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD MFGEEESYNP DKVT
Explore Cadherin-12 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets